Biopharmaceutics And Pharmacokinetics By C.v.s. ✰

c) Discuss factors affecting drug absorption from the gastrointestinal tract. (8) d) Write a short note on Dissolution and Noyes-Whitney equation . (7) Q3. (Long Answer – 15 Marks) a) Derive the equation for one-compartment open model – IV bolus. Calculate elimination rate constant (K) given data. (8) b) Explain volume of distribution (Vd) – significance and factors affecting it. (7)

c) Derive the equation for oral absorption (one-compartment model) – method of residuals. (8) d) Define flip-flop kinetics – when does it occur? (7) Q5. (Long Answer – 15 Marks) a) Explain protein binding of drugs – mechanisms, factors affecting, and clinical importance. (8) b) Describe renal excretion of drugs: glomerular filtration, tubular secretion, and reabsorption. (7) Biopharmaceutics And Pharmacokinetics By C.v.s.

c) Write a note on Hepatic clearance – intrinsic clearance, extraction ratio (ER), high & low extraction drugs. (8) d) Define First-pass metabolism with examples. (7) Q6. (Long Answer – 15 Marks) a) Discuss multiple dosing – steady-state concentration (Css), accumulation index, and loading dose. (8) b) What are In-vitro – In-vivo correlation (IVIVC) ? Levels of correlation. (7) c) Discuss factors affecting drug absorption from the

It sounds like you’re asking for a (question paper) based on the textbook Biopharmaceutics and Pharmacokinetics by Dr. C.V.S. Subrahmanyam (a very common reference in Indian pharmacy courses, especially for B.Pharm). (Long Answer – 15 Marks) a) Derive the